Chemical robots

3D Printing

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Prototyping and parametric design of
3D printed tablets

Cancer Theranostics

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Microgel bioreactors for
cancer cell targeting

Chemistry on Demand

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Magnetic liposome aggregates for
on-demand release of payloads

Encapsulation Technologies

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Multi-compartmental drug carriers by
aggregation of microgels

Pharmaceutical Engineering

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Production of multi-crystals by
crystallization in a fluidic device

Structured Silica Particles

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Silica with hierarchical porosity for
melt amorphisation of drugs

And 165 more publications

 

The Chemical Robotics Laboratory was established by Prof. František Štěpánek in 2008 as part of the Chemical Engineering Department at the University of Chemistry and Technology Prague. Our research is focused on the design and synthesis of structured particles and particle systems in two main areas - in "traditional" Particle Technology (granulation, spray drying, crystallization, dissolution) and in the emerging field of Chemical Robotics. Our aim is to conceive microscopic chemical robots that mimic single-cell organisms in that they are capable of autonomous movement, they have the ability to store, chemically process and release molecules on demand, and they can recognize the target by specific adhesion. Unlike living organism, they cannot evolve or self-replicate, but they can be remotely controlled - thus the name "robots". Find out more about our research interests.

Composition of a chemical robot:

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Composition of a Chemical Robot

1st step

Porous or breakable shell with hollow core in size range from hundreds of nanometers up to tens of micrometers

2nd step

Core filled with active substance or other needed medium

3rd step

Encapsulation of inner compartments which are carriers of other active substances

4th step

Incorporation of iron oxide nanoparticles to enable radiofrequency heating

5th step

Modification of the surface of the shell with selective adhesive layer

6th step

An outside stimuli triggers a release mechanism and active substances are spread out into the surrounding environment