Solid lipid nanoparticles

Lucie Vidlářová, Jarmila Zbytovská, František Štěpánek

Lipid nanoparticles are spherical particles with potential encapsulation of pharmaceutical or cosmetic actives. Their size ranges from 30-100 nm and depends on the amount of lipids and surfactants used in the preparation process.

Recent progress in nanotechnology shows that particles can be efficient carrier systems for drug delivery through the skin barrier. The application of lipid-based systems in the treatment of skin diseases might avoid adverse effects such as skin thinning or irritation.

The aim of this study is to design dermal drug delivery systems with deep understaning of skin penetration enhancement. Currently we investigate the skin penetration profile of a model lipophilic dye delivered by lipid nanopartiles by confocal laser microscopy. The obtained images are further analyzed by novel statistically robust quantitative image analysis.

Schematic picture of drug delivery to the skin. On the left - drug do not penetrate through the skin barrier, on the right - lipid nanoparticles promote the penetration of the drug to the deeper layers of the skin.

Schematic picture of drug delivery to the skin. On the left – drug do not penetrate through the skin barrier, on the right – lipid nanoparticles promote the penetration of the drug to the deeper layers of the skin.

Cross-sectional fluorescent image of porcine skin treated with A) dye simply dissolved in oil and B) dye encapsulated to lipid nanoparticles.

Cross-sectional fluorescent image of porcine skin treated with A) dye simply dissolved in oil and B) dye encapsulated to lipid nanoparticles.