Equipment

Laboratory

Chemical robotics laboratory was established in 2008. In the beginning we operated only from two refurbished, fully air-conditioned laboratories of approximately 90 m² total floor area in the room B308 in the building B of University of Chemistry and Technology Prague. The smaller “wet” chemistry lab was adjacent to a larger “clean” physical and characterisation lab (see laboratory photogallery 2008, 2009). In 2010 we got an office room next to this lab (room B307). The head of the group prof. Stepanek is sitting in the room BS64. In 2012 we got the room BS67 and repurposed it to serve as a clean laboratory for biological experiments. In 2013 we have acquired the MRI device and with it the room BS52 which was reconstructed and now it also houses our 3D printers. The latest addition to the CHOBOTIX groups room collection is the room BS62, reconstructed in 2015, where you can find a fully equipped lab with a large walk-in hood and a dark room. It is adjoined by an office, a small meeting room and a small kitchen.

Major Instruments

Bruker ICON – MRI desktop system

MRI desktop system ICON (Bruker)

  • compact and easy-to-use cryogen-free high-performance MRI desktop system
  • MRI scanner for small rodents like rats and mice

 

Malvern NanoSight NS300 – nanoparticle tracking system

  • NanoSight_NS300rapid and automated size distribution and concentration analysis
  • particle size range of 10 nm to 2000 nm
  • enhanced fluorescence detection capability

NANO-flex – 180° DLS Size analyser

  • NANOflex 180suitable for concentrations up to 40% vol.
  • suitable for broad size distributions
  • particle size range of 0.8 nm to 6500 nm

Sirius Surface Dissolution UV Imager

  • SiriusSDIreal-time UV videos of the dissolution process
  • static or under flow
  • 2D array of pixels

Brookfield CT3 Texture Analyser

  • CT3 texture analyserboth compression and tensile testing
  • six built-in test modes, up to 50 kg
  • a variety of detachable testing probes

PION µDISS Profiler – Miniaturized in situ Concentration Monitoring

  • PION udiss profilerSmall Volume Dissolution (2-20 mL)
  • in situ UV Monitoring (200 -720 nm)
  • Individually Controlled 8 Channel Stirring
  • Interchangeable pathlehgth probe tips

Horiba Partica LA-950 S2 particle size analyser

Horiba Partica

  • dual laser source of 650 nm and 405 nm
  • particle size range of 10 nm to 5000 μm
  • three measuring cells: dry, wet, and fraction cell

Jeol JCM-5700 Scanning Electron Microscope

  • high and low vacuum mode
  • secondary and backscatter electron imaging
  • spatial resolution up to 5 nm

SkyScan Micro-CT SEM attachment

SkyScan Micro-CT SEM attachment

  • x-ray microtomography in SEM
  • spatial resolution of up to 800 nm
  • 3D volume visualisation and analysis

 

ThermoScientific Evolution 220 UV-Visible Spectrophotometer

Evolution 220

  • Double beam
  • Single Xenon flash lamp with 190-1100 nm range
  • Smart 8-Cell Peltier system for temperature control

Specord 205 BU uv-vis spectrophotometer

Specord 205 BU uv-vis spectrophotometer

  • double beam
  • spectral range 190-1100 nm, slit width 1.4 nm
  • turbid samples

Agilent Cary Eclipse Fluorescence SpectrophotometerAGILENT CARY ECLIPSE FLUORESCENCE SPECTROPHOTOMETER

  • Fluorescence, phosphorescence, chemi/bio-luminescence
  • 4-cell thermostatted sample holder
  • 2 temperature probes

Malvern Zetasizer Nano-ZS

Malvern Zetasizer Nano-ZS

  • Dynamic Light Scattering, Static Light Scattering
  • Particle size range 0.6 nm – 6 μm
  • Zeta potential – in aqueous and non-aqueous dispersions

 

Laser Scanning Confocal Microscope

Laser Scanning Confocal Microscope

  • Olympus Fluoview FV1000 confocal system
  • Olympus IX81 inverted microscope base

FTIR system

IMG_6892 medium

  • Nicolet iN10 infrared microscope
  • Nicolet iZ10 FTIR module with ATR accessory

Mini Spray Dryer B-290 with Inert Loop B-295

  • Spray drier with inert loopProduce dry particles in range 1 – 25 μm
  • Suitable also for heat sensitive materials (short residence time)
  • Possibility to use organic solvents (in combinations with Inert Loop)

Encapsulator B-395 Pro

  • B-395microencapsulatordevice for controlled encapsulation of cells, biological and active materials for labscale R&D work
  • technique for monodisperse particle production
  • fully autoclavable production system (reaction vessel) enables obtainment of a completely sterile environment, if required

3D Printer MakerBor Replicator 2X

replicator-2x

  • resolution up to 100 micron
  • dual extrusion
  • ABS or PLA filaments

Smaller Equipment

  • Olympus stereo microscope and inverted microscope with CCD cameras
  • Precision balances
  • Vacuum drying oven
  • Ultrasound generator
  • Colloid mill
  • Vibration ball mill
  • Drop-on-demand print head
  • Centrifuge
  • Spin coater
  • Demineralised water generator
  • Freeze dryer
  • Rotary evaporator